I just started to take a look at Folding@Home / Life with Playstation. There are several little details which are pretty interesting.
One thing which got me interested, is that the "game" has more permissions than any other game or application. Normal games do not have access to the root of /dev_hdd0/ but F@H has.
It can read, write and execute which was found out as it creates a folder called /cntlnk/ in /dev_hdd0/. There it caches several music files you play while running the application. This is handled via a SQL Lite Format 3 DB (db1.1.sqlite) in /NPIA00002/USRDIR/data/wlop/.
Another thing is, that F@H/LWP can override the PARAM.SFO. Normally the option window when u press triangle in XMB on a game just reads the data, PARAM.SFO passes to it. But here, the automatic start option is not loaded via the .sfo. It seems it comes from an external XML file in the game directory.
The last I want to write about now is, that older F@H versions were able to control the SPU's partly. For example it was possible to define how many SPU's are used at all.
These are just some points that came up so far. I will keep you updated when there is more!